Aging is associated with highly defined epigenetic changes in the human epidermis

Maintained memory in aging is associated with young epigenetic age

Epigenetic alterations during aging have been proposed to contribute to decline in physical and cognitive functions, and accelerated epigenetic aging has been associated with disease and all-cause mortality later in life. In this study, we estimated epigenetic age dynamics in groups with different memory trajectories (maintained high performance, average decline, and accelerated decline) over a...

Serum Level of Soluble CD226 Receptor in Healthy Individuals is Highly Variable and Associated with Age

Is Life Expectancy Associated with Depression in the Elderly?

Introduction: Depression is one of the most common psychiatric disorders and risk factors for suicide in aging that often underdiagnosed and those who are more hopeful, suffer from less depression. The present study was conducted to determine the relationship between life expectancy and depression among older people in Yazd, Iran.   Methods: This descriptive cross-sectional study was con...

Changes in thrombelastograph variables associated with aging.

Aging is associated with hypercoagulability. To assess thrombelastography (TEG) variables associated with aging, 132 adult patients of various ages undergoing orthopedic surgery for fracture repair had venous blood samples withdrawn for testing of recalcified TEG before the induction of anesthesia. Age was weakly correlated with all TEG variables: r time (R) (r = -0.45, P < 0.001; R = 19.5 - 0....

Epigenetic Mechanisms of the Aging Human Retina

Degenerative retinal diseases, such as glaucoma, age-related macular degeneration, and diabetic retinopathy, have complex etiologies with environmental, genetic, and epigenetic contributions to disease pathology. Much effort has gone into elucidating both the genetic and the environmental risk factors for these retinal diseases. However, little is known about how these genetic and environmental...